Life's Instruction Manual: Interactive Lesson | UNC-TV Science

Learning Resource Type

Classroom Resource

Subject Area

Science

Grade(s)

9, 10, 11, 12

Overview

The human genome serves as an instruction manual for life, with its own distinct letters, alphabet, sentences, and chapters. Learn about the genome, nucleotides, DNA, and genes with this interactive lesson.

Science (2015) Grade(s): 09-12 - Biology

SC15.BIO.3

Formulate an evidence-based explanation regarding how the composition of deoxyribonucleic acid (DNA) determines the structural organization of proteins.

UP:SC15.BIO.3

Vocabulary

  • Nitrogenous bases
  • Deoxyribose
  • Phosphates
  • Hydrogen bonding
  • Nucleotides
  • Semi-conservative replication
  • Central Dogma
  • Transcription
  • Various types of RNA, including those involved in protein synthesis (mRNA, tRNA & rRNA) and those associated with gene regulation (e.g., IncRNA, miRNA, siRNA) and post-transcriptional modification (snRNA)
  • RNA polymerase
  • Introns
  • Exons
  • Codon
  • Translation
  • Anticodon
  • Deletion
  • Insertion
  • Substitution
  • Variant
  • DNA sequencing
  • PCR
  • Gel electrophoresis
  • Big Science Projects conducted over last 30 years: Human Genome Project, The International Hap Map, ENCODE, Cancer Genome Atlas, 1000 Genomes project, ClinVar and ClinGen, and the Exome Aggregation
  • Consortium.
  • Deletion
  • Insertion
  • Translocation
  • Substitution
  • Inversion
  • Frameshift mutations
  • Point mutations

Knowledge

Students know:
  • All living things have DNA How the 5' and 3' orientation of DNA nucleotides results in the antiparallel nature of DNA.
  • The complementary nature of nitrogenous bases.
  • How hydrogen bonding holds complementary bases together across two DNA strands.
  • The basic mechanism of reading and expressing genes is from DNA to RNA to Protein (The Central Dogma of Biology).
  • The first step of the Central dogma is a process called transcription, which synthesizes mRNA from DNA.
  • The process where the mRNA connects to a ribosome, the code is read and then translated into a protein is called translation.
  • To become a functional protein, a translated chain of amino acids must be folded into a specific three-dimensional shape.
  • Historically important experiments that led to the development of the structure of DNA, including Mieshcer, Chargraff, Rosalind Franklin, Watson/Crick, etc.
  • DNA changes can be linked to observable traits in the natural world, such as diseases.
  • Common laboratory techniques are used to obtain evidence that supports the premise that DNA changes may affect proteins and in turn the appearance of traits.
  • Types of errors that can occur during replication and the impact these errors have on protein production and/or function.

Skills

Students are able to:
  • Build from scratch or work with previously constructed models of DNA to identify the key structural components of the molecule.
  • Obtain and communicate information (possibly through a conceptual model) describing how information encoded in DNA leaves the nucleus.
  • Obtain and expand explanation to include how the information transcribed from DNA to RNA determines the amino acid sequence of proteins.
  • Identify and describe the function of molecules required for replication and differentiate between replication on the leading and lagging DNA strands.
  • Group mRNA into codons and identify the amino acid associated with each codon. Create and manipulate polypeptide models to demonstrate protein folding.
  • Use a variety of resources (web-based timelines, original publications, documentaries, and interviews), explain how historically important experiments helped scientists determine the molecular structure of DNA, and develop the concept of the Central Dogma of Biology.
  • Analyze a variety of diagnostic techniques that identify genetic variation in a clinical setting.
  • Relate protein structure to enzyme function and discuss the causes and impacts of protein denaturation on both enzymes and structural proteins.
  • Identify the impact of DNA changes on the structure and/or function of the resulting amino acid sequences.
  • Predict the impact of errors during DNA replication in terms of protein production and/or function.
  • Classify types of DNA changes (deletions, insertions, and substitutions).
  • Use models to explain how deletions, insertions, translocation, substitution, inversion, frameshift, and point mutations occur during the process of DNA replication.

Understanding

Students understand that:
  • The traits of living things are ultimately determined by inherited sequences of DNA.
  • The end product of transcription is always RNA, but the process produces many different types of RNA with varying functions.
  • DNA instructions are replicated and passed from parent to offspring, segregating traits across generations in a mathematically predictable manner.
  • A protein is a linear sequence of amino acids that spontaneously folds following rules of chemistry and physics.
  • A series of historically important experiments let to the current understanding of the structure of DNA and the Central Dogma of Biology.
  • Errors that occur during DNA replication can affect protein production and/or function. Important projects over the past 30 years have changed the definition of a "gene" and increased the ability to assess the impact of DNA variation in a trait or disease.
  • Genetic change can lead to altered protein function and the appearance of a different trait or disease.

Scientific and Engineering Practices

Engaging in Argument from Evidence; Obtaining, Evaluating, and Communicating Information

Crosscutting Concepts

Patterns

CR Resource Type

Interactive/Game

Resource Provider

PBS

License Type

Custom
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