SC15.BIO.4

Science (2015) Grade(s): 09-12 - Biology

SC15.BIO.4

Develop and use models to explain the role of the cell cycle during growth and maintenance in multicellular organisms (e.g., normal growth and/or uncontrolled growth resulting in tumors).

Unpacked Content

Scientific and Engineering Practices

Developing and Using Models

Crosscutting Concepts

Systems and System Models

Knowledge

Students know:
  • The phases of the cell cycle (Interphase-G1, S, and G2 phases, Mitosis and cytokenisis), the amount of time spent in each cycle and what occurs during each cycle.
  • The process of cell cycle regulation.
  • Mechanisms, checkpoints and signaling factor molecules that regulate the cell cycle.

Skills

Students are able to:
  • Generate a graphic illustrating the amount of time a cell spends in each phase of the cell cycle.
  • Observe video, image or microscope slide and identify cells in each phase, relative abundance, and estimate the time spent in each phase.
  • Obtain and communicate information about the relationship between the cell cycle and the growth and maintenance of an organism.
  • Illustrate chromosome behavior during mitosis using chromosome models.
  • Distinguish between replicated and un-replicated chromosomes.
  • Demonstrate the events and cellular processes involved in each stage of mitosis.
  • Investigate the impact of errors in the process of cell division.
  • Identify the basic mechanisms, checkpoints, and general categories of signaling factor molecules (both internal and external).
  • Relate errors in control mechanisms to uncontrolled cell growth (cancer).

Understanding

Students understand that:
  • The cell cycle is necessary for growth and maintenance in multi-cellular organisms.
  • Mitosis only makes somatic (body) cells.
  • Errors in control mechanisms within the cell cycle lead to uncontrolled cell growth (cancer).

Vocabulary

  • Cell cycle
  • Chromosome
  • Somatic cell
  • Chromatin
  • Spindle fibers
  • Kinetochore microtubules
  • Centrioles
  • Centrosome
  • Centromere
  • Sister chromatids
  • Mitosis
  • Prometaphase
  • Prophase
  • Metaphase
  • Metaphase plate
  • Anaphase
  • Telophase
  • Cytokinesis
  • Cell plate
  • Cleavage furrow
  • Interphase
  • S phase
  • G1
  • G2
  • Growth
  • Maintenance
  • Checkpoints
  • Signaling factors

Aligned Learning Resources

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